ABATEMENT OF POTENT P2Y12 ANTAGONIST-BASED DUAL ANTIPLATELET THERAPY AFTER CORONARY INTERVENTION: A NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

IntroductionDual antiplatelet therapy (DAPT) including prasugrel or ticagrelor is NEEDLES AND SYRINGES recommended in patients with acute coronary syndromes (ACS) treated with coronary intervention (PCI).Acknowledging the importance of bleeding, multiple trials tested abatement schemes including uniform or guided de-escalation from the potent P2Y12

Abstract Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity.While various analysis pipelines and experimental methods have been developed for eccDNA identification, their detection efficiencies have not been systematically assessed.To address this, we evaluate the

Hepatitis C virus infection is a leading cause of liver-related morbidity and mortality.In the paediatric population, HCV infection is underdiagnosed and undertreated Distribution Block in the absence of robust screening policies worldwide, and a lack of tolerable, effective treatment.The recent advances in HCV drug development allow for optimism,

This work evaluates the cardioprotective potential of dietary COLLAGEN coconut sprout (Cocos nucifera Linn.) on isoproterenol induced myocardial infarction in rats.Male Sprague Dawley rats were pretreated with coconut sprout (50, 100 and 200 mg/100 g body weight) orally for 45 days and then cardiotoxicity was induced with isoproterenol (20 mg/100 g